Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
Brief Communication
Cardiac Critical Care, Case Report
Cardiac Critical Care, Case Series
Cardiac Critical Care, Editorial
Cardiac Critical Care, Invited Editorial
Cardiac Critical Care, Original Article
Cardiac Critical Care, Point of Technique
Cardiac Critical Care, Review Article
Case Report
Case Report, Cardiac Critical Care
Case report, Cardiology
Case Series, Cardiac Critical Care
Editorial
Editorial, Cardiac Critical Care
Invited Editorial, Cardiac Critical Care
JCCC Quiz, Cardiac Critical Care
Legends in Cardiac Sciences
Letter To Editor Response
Letter to Editor, Cardiac Anesthesia
Letter to Editor, Cardiac Critical Care
Letter to the Editor
Narrative Review, Cardiac Critical Care
Notice of Retraction
Original Article
Original Article, Cardiac Critical Care
Original Article, Cardiology
Perspective Insights
Perspective, Cardiac Critical Care
Point of Technique
Point of Technique, Cardiac Critical Care
Point of View, Cardiac Critical Care
Review Article
Review Article, Cardiac Critical Care
Review Article, Cardiology
Review Article, Evidence Based Medicine
Review Article, Invited
Short Communication, Cardiac Critical Care
Surgical Technique
Surgical Technique, Cardiac Critical Care
Surgical Technique, Cardiology
Systematic Review
Technical Note
Video Case Report
Video Commentary
Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
Brief Communication
Cardiac Critical Care, Case Report
Cardiac Critical Care, Case Series
Cardiac Critical Care, Editorial
Cardiac Critical Care, Invited Editorial
Cardiac Critical Care, Original Article
Cardiac Critical Care, Point of Technique
Cardiac Critical Care, Review Article
Case Report
Case Report, Cardiac Critical Care
Case report, Cardiology
Case Series, Cardiac Critical Care
Editorial
Editorial, Cardiac Critical Care
Invited Editorial, Cardiac Critical Care
JCCC Quiz, Cardiac Critical Care
Legends in Cardiac Sciences
Letter To Editor Response
Letter to Editor, Cardiac Anesthesia
Letter to Editor, Cardiac Critical Care
Letter to the Editor
Narrative Review, Cardiac Critical Care
Notice of Retraction
Original Article
Original Article, Cardiac Critical Care
Original Article, Cardiology
Perspective Insights
Perspective, Cardiac Critical Care
Point of Technique
Point of Technique, Cardiac Critical Care
Point of View, Cardiac Critical Care
Review Article
Review Article, Cardiac Critical Care
Review Article, Cardiology
Review Article, Evidence Based Medicine
Review Article, Invited
Short Communication, Cardiac Critical Care
Surgical Technique
Surgical Technique, Cardiac Critical Care
Surgical Technique, Cardiology
Systematic Review
Technical Note
Video Case Report
Video Commentary
Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
Brief Communication
Cardiac Critical Care, Case Report
Cardiac Critical Care, Case Series
Cardiac Critical Care, Editorial
Cardiac Critical Care, Invited Editorial
Cardiac Critical Care, Original Article
Cardiac Critical Care, Point of Technique
Cardiac Critical Care, Review Article
Case Report
Case Report, Cardiac Critical Care
Case report, Cardiology
Case Series, Cardiac Critical Care
Editorial
Editorial, Cardiac Critical Care
Invited Editorial, Cardiac Critical Care
JCCC Quiz, Cardiac Critical Care
Legends in Cardiac Sciences
Letter To Editor Response
Letter to Editor, Cardiac Anesthesia
Letter to Editor, Cardiac Critical Care
Letter to the Editor
Narrative Review, Cardiac Critical Care
Notice of Retraction
Original Article
Original Article, Cardiac Critical Care
Original Article, Cardiology
Perspective Insights
Perspective, Cardiac Critical Care
Point of Technique
Point of Technique, Cardiac Critical Care
Point of View, Cardiac Critical Care
Review Article
Review Article, Cardiac Critical Care
Review Article, Cardiology
Review Article, Evidence Based Medicine
Review Article, Invited
Short Communication, Cardiac Critical Care
Surgical Technique
Surgical Technique, Cardiac Critical Care
Surgical Technique, Cardiology
Systematic Review
Technical Note
Video Case Report
Video Commentary
View/Download PDF

Translate this page into:

Letter to the Editor
3 (
1
); 51-52
doi:
10.1055/s-0039-1696906

Anaphylaxis-Induced Atrial Fibrillation and Anesthesia: Are We Missing Something?

Department of Cardiac Anaesthesia, Cardiothoracic Sciences Centre, All India Institute of Medical Sciences, New Delhi, India

Minati Choudhury, MD, PGDip, Department of Cardiac Anaesthesia, Cardiothoracic Sciences Centre, All India Institute of Medical Sciences, Room No.10, New Delhi 110 029, India minatichoudhury2002@yahoo.co.in

Licence
This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
Disclaimer:
This article was originally published by Thieme Medical and Scientific Publishers Private Ltd. and was migrated to Scientific Scholar after the change of Publisher.

Brief Communication

Atrial fibrillation (AF) represents a complex cardiac arrhythmia, which is related to various risk factors, such as aging, allergy, oxidative stress, hypertension, cardiovascular diseases (CVD), diabetes mellitus or thyrotoxicosis.1 recently, several reports have been published associating atrial fibrillation with anaphylactic reaction from food consumption, mitochondrial dysfunction. All these causative factors are interrelated and can exist in the same patients.2 The relationship between anaphylaxis and cardiovascular event is important. It is also true that fatal cardiovascular events (atrial or ventricular fibrillation) represent the leading cause of death in anaphylaxis.

The heart is the primary source and target of several mediators released during anaphylaxis. The release of these mediators influences heart rate (HR), coronary tone, and ventricular function. Some of the commonly used drugs during the perioperative period, for example, β-lactam antibiotics, anaesthetics, N-acetylcysteine, and antiarrhythmic drugs itself are also noted to be responsible for the development of AF during anaphylaxis.2 Diseases of cardiovascular system also increases the risk of catastrophic anaphylaxis as well as AF, for example, mast cell mediates acute coronary syndrome and drugs used for CVD treatment, especially ACE inhibitors and β-blockers possibly exacerbate anaphylaxis or make it more complicated to manage.2 What is more important to know in such condition is that, which should be first, the treatment of several other common symptoms of anaphylaxis or AF ? Moreover, when all the etiologies present in the same patient, at times, it is difficult to treat the AF.

Control of HR and prevention of complications of AF, for example, hypotension and heart failure, are essential. The American Heart Association/Heart Rhythm Society recommends intravenous β-blocker or calcium channel blockers especially the nondihydropyridine group of drugs (verapamil or diltiazem) to reduce the ventricular rate in the presence of sudden AF in the absence of an accessory pathway.3 Amiodarone as a class I recommendation in the presence of heart failure with AF without accessory pathway and a class IIa recommendation for control of HR in AF if other routinely used control agents failed or contraindicated. Amiodarone is the most frequently used agent for AF despite it harboring an extensive side effect. In case of isolated AF, β blocker may be tried first but sotalol, propafenone, and flecainide are particularly effective. Esmolol at a dose of 500 µg/kg over 1 minute followed by infusion at 50–200 µg/kg/min is preferred due to its quick onset of effect and short duration of action. Diltiazem at a dose of 0.25 mg/kg followed by 5–15 mg/h infusion is also effective in the emergency scenario. However, both β blocker and CCB are associated with the risk of hypotension, heart block, and heart failure. Beta blockers are contraindicated in patients with asthma. Electrical cardioversion is recommended in hemodynamically unstable patients. Patient should be investigated for underlying coexisting problem if AF is persistent (more than 7 days). Treatment with H1 antagonist is controversial because these drugs slow atrioventricular conduction and inhibit ventricular fibrillation, and they are considered to be safe in AF.4 Corticosteroids help during oxidative stress, and no contraindication have been described in the existing literature in case of AF. The benefits of antioxidant therapy using vitamins C and E, polyunsaturated fatty acid, statin, or nitric oxide donor in the prevention of AF are well described in various preclinical studies and clinical trials; however, the benefits of these agents during acute care settings are yet to be proved.3 In spite of the fact that, the genetic basis of origin of both anaphylaxis and AF has been essentially proved, and the application of this understanding in the management of patients with AF during anaphylaxis has not happened so far. Some evidence indicates that AF patients who are carriers of the common chromosome 4q25 single-nucleotide polymorphism (SNP) respond to pharmacological therapy differently from individuals without these SNPs. There is always a hesitation to utilize this genetic data to bedside. This is probably due to the fact that prospective clinical trial to validate the common AF risk alleles is not available.5

Patients with acute coronary syndrome with developed anaphylaxis and AF need to be considered along with the benefits and potential harm of epinephrine which is considered to be the life-saving drug in acute care setting. One has to weigh the potential adverse effect of this drug against the possible death from untreated anaphylaxis. No absolute contraindication of the use of epinephrine during anaphylaxis is described elsewhere in literature.

Perioperative anaphylaxis is increasing as anesthesia protocols become more complex. Resultant AF may have life-threatening consequences. Therefore, any suspected reaction must be extensively investigated to the root cause to provide precise recommendation for future anesthetic management.

Conflict of Interest

None.

Financial Support None.

References

  1. , , , , , . Twelve-year survey of fatal reactions to allergen injections and skin testing: 1990-2001. J Allergy Clin Immunol. 2004;113(6):1129-1136.
    [Google Scholar]
  2. , , , , , . Allergy and the cardiovascular system. Clin Exp Immunol. 2008;153(01):7-11.
    [Google Scholar]
  3. , , , et al . American College of Cardiology/American Heart Association Task Force on Practice Guidelines; European Society of Cardiology Committee for Practice Guidelines; European Heart Rhythm Association; Heart Rhythm Society. ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the European Society of Cardiology Committee for practice guidelines (writing committee to revise the 2001 guidelines for the management of patients with atrial fibrillation): developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Circulation. 2006;114(7):e257-e354.
    [Google Scholar]
  4. , . The heart in anaphylaxis. J Allergy Clin Immunol. 1986;77(5):663-666.
    [Google Scholar]
  5. , , . Biological therapies for cardiac arrhythmias: can genes and cells replace drugs and devices? Circ Res. 2010;106(4):674-685.
    [Google Scholar]

Fulltext Views
417

PDF downloads
291
View/Download PDF
Download Citations
BibTeX
RIS
Show Sections